Evaluation of a new mouthwash formulated with Chlorhexidine and Cymenol after a scaling and root planing treatment in grade I and II periodontal patients

• Paula Hermida-Cabrera ^[1] ; Felipe-Rodrigo Aguilera ^[3] ; Fernando Vivancos-Cuadras ^[4] ; Lourdes Ferrá-Domingo ^[5] ; Daniel Torres-Lagares ^[1] ; José-Luis Gutiérrez-Pérez ^[1] ; Tanya Pereira-Riveros ^[2] ; Teresa Vinuesa ^[2] ; María-Ángeles Serrera-Figallo ^[1] ; María Baus-Domínguez ^[1]
  1. [1] Universidad de Sevilla

     Universidad de Sevilla

     Sevilla, España

     
  2. [2] Universitat de Barcelona

     Universitat de Barcelona

     Barcelona, España

     
  3. [3] Unit of Microbiology, Department of Pathology and Experimental Therapeutics, Faculty of Medicine and Health Sciences, University of Barcelona, L’Hospitalet de Llobregat, Barcelona, Spain; School of Dentistry, Faculty of Medicine, Universidad Austral de Chile, Valdivia, Chile
  4. [4] LACER Medical Department, Barcelona, Spain
  5. [5] LACER R&D/Microbiology Department, Barcelona, Spain

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• Localización: Medicina oral, patología oral y cirugía bucal. Ed. inglesa, ISSN-e 1698-6946, Vol. 29, Nº. 6 (Noviembre), 2024
• Idioma: inglés
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• Resumen

  • Periodontal disease (PD) is a chronic inflammatory disease of multifactorial origin that affects the supporting tissues of the tooth. According to WHO in 2022, severe periodontal disease will affect around 19% of the adult population worldwide. Its risk factors include the presence of periodontopathogenic bacteria in biofilm and the susceptibility of the host’s immune system, among others. Preterm birth is defined as birth occurring before 37 weeks of gestational age. It also has a multifactorial origin and it’s associated with risk factors such as intrauterine and extrauterine infections. There is a possibility that periodontal disease in pregnant women increases the risk of preterm birth through hematogenous pathways or the presence and intervention of inflammatory mediators.

    Through a systematic review of existing scientific articles from 2014 to 2024, five randomized clinical trials were selected, including a total of 1984 pregnant patients diagnosed with periodontal disease. Half of these patients received non-surgical treatment, while the other half did not, aiming to evaluate a possible association between periodontal disease and/or its treatment and the occurrence of preterm birth. The risk of bias was assessed using the Cochrane “RoB 2” tool, and finally, a meta-analysis was conducted to compare the results obtained in the selected studies.

    Four articles showed a trend favoring non-surgical periodontal treatment as a preventive measure for preterm birth. These articles accounted for 92.2% of the total weight, while the remaining 7.85% corresponded to the single article that did not favor the treatment. However, none of the articles showed statistically significant results.

    There is no demonstrated association between periodontal disease in pregnant women and the incidence of preterm birth. On the other hand, there is a slightly favorable trend towards non-surgical periodontal treatment during pregnancy as a measure to reduce the incidence of preterm birth, but it’s not statistically significant. To obtain a definitive answer, more randomized clinical trials following similar study and design parameters are needed.