Association of smoking with disease progression in persons with multiple sclerosis undergoing autologous hematopoietic cell transplantation: a single-center experience

Danitza Fernandez Lara; José Manuel Porcel Pérez; Robinson Robles Hernández; Olivia Lira Lara; Miranda Melgar de la Paz de la Paz; Moisés M. Gallardo Pérez; Juan C. Olivares Gazca; Guillermo j. Ruiz Delgado; Guillermo José Ruiz Argüelles

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Association of smoking with disease progression in persons with multiple sclerosis undergoing autologous hematopoietic cell transplantation: a single-center experience

Danitza Fernandez Lara ^[5] ; José Manuel Porcel Pérez ^[1] ; Robinson Robles Hernández ^[2] ; Olivia Lira-Lara ^[3] ; Miranda Melgar de la Paz de la Paz ^[4] ; Moisés M. Gallardo Pérez ^[5] ; Juan C. Olivares Gazca ^[5] ; Guillermo j. Ruiz Delgado ^[4] ; Guillermo José Ruiz Argüelles ^[4]
1. [1] Hospital Universitario Arnau de Vilanova
  
  Hospital Universitario Arnau de Vilanova
  
  Lérida, España
2. [2] Instituto Nacional de Enfermedades Respiratorias
  
  Instituto Nacional de Enfermedades Respiratorias
  
  México
3. [3] Universidad Veracruzana
  
  Universidad Veracruzana
  
  México
4. [4] Universidad Anáhuac
  
  Universidad Anáhuac
  
  México
5. [5] Centro de Hematología y Medicina Interna, Clínica Ruiz, Puebla, Mexico
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Localización: Revista de investigación clínica, ISSN 0034-8376, ISSN-e 2564-8896, Vol. 76, Nº. 5, 2024, págs. 223-229
Idioma: inglés
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Resumen
- Smoking remains a significant issue that increases the prevalence of multiple sclerosis (MS) and its progression to secondary progressive forms. Objectives: The goal is to identify the relationship between smoking and disease progression in MS patients who have undergone autologous hematopoietic stem cell transplantation (auto-HSCT) at the Centro de Hematología y Medicina Interna, Clínica Ruiz, Puebla, Mexico. Methods: This retrospective study involved MS patients treated with auto-HSCT, followed for 12 months. The response to transplantation was measured using the difference in Expanded Disability Status Scale (EDSS) scores before and 12 months after the transplant. A difference of −0.5 or greater indicated a good response, while a difference below 0.5 indicated a poor response. Results: The study included 419 patients, with a median age of 47 years (IQR: 40-53). The majority were non-smokers (315) compared to smokers/ex-smokers (104). In patients with PMSS, EDSS stabilization at 12 months was observed in both smokers/ex-smokers (median 6, interquartile range (IQR) = 1 vs. 6, IQR = 1, p = 0.466) and non-smokers (median 6, IQR = 1 vs. 6, IQR = 1.5, p = 0.001), although non-smokers showed a statistically significant difference. Conclusion: Smoking may negatively impact MS progression, especially in its progressive forms.