Resumen de Paziente eskizofreniko eta kontrolen garun kortexean D2, CB1 eta mGlu2 hartzaileen espresio aldakortasunaren ikerketa
Jon de la Cuesta Barrutia, Olga Peñagarikano Ahedo, Luis Felipe Callado Hernando, José Javier Meana Martínez, Alfredo Ramos Miguel, Amaia Erdozain Fernández
- English
Schizophrenia is a serious psychiatric disorder where dopaminergic, cannabinoid, and glutamatergicneurotransmission systems are severely affected. Expression of receptors part of these systemsconsisting in dopamine D2, cannabinoid CB1, and metabotropic glutamate mGlu2 are analysed in theprefrontal cortex of post-mortem brains of schizophrenia and control subjects. For this purpose,Western Blot technique based on fluorescence and chemiluminescence is employed. As result, asignificant reduction in the expression of CB1 and mGlu2 receptors is found in schizophrenics, andantipsychotic treatment also contributes in this decline. Nonetheless, no significant alteration isobserved for D2 receptor.
- euskara
glutamatergikoaren asaldura dagoen. Ikerketa honetan sistema hauen parte diren D2 dopamina, CB1kannabinoide eta mGlu2 glutamato hartzaileen espresioa aztertzen da subjektu eskizofreniko etakontrolen post-mortem garunen kortex prefrontalean. Honetarako, fluoreszentzian etakimioluminiszentzian oinarritutako Western Blot teknika erabili da. Honenbestez, CB1 eta mGlu2hartzaileen espresio murrizpen esanguratsua aurkitu da eskizofrenikoetan, antipsikotikoentratamenduaren eraginak ere honetan lagunduz. Alabaina, D2 hartzailearekiko ez da inolakodesberdintasun esanguratsurik antzeman.
