A case with recurrent idiopathic anaphylaxis episodes starting soon after COVID-19 mRNA vaccination

• Pelin Korkmaz ^[1] ; Semra Demir ^[1] ; Deniz Eyice Karabacak ^[1] ; Derya Unal ^[1] ; Asli Gelincik ^[1]
  1. [1] Istanbul University

     Istanbul University

     Turquía

     
• Localización: Allergologia et immunopathologia: International journal for clinical and investigate allergology and clinical immunology, ISSN-e 1578-1267, ISSN 0301-0546, Vol. 52, Nº. 6, 2024, págs. 58-61
• Idioma: inglés
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• Resumen

  • Introduction: A patient was presented with a history of idiopathic recurrent anaphylaxis after administration of Pfizer BioNTech mRNA vaccine, and the attacks were controlled with omalizumab. To our knowledge, this is the first reported case of recurrent idiopathic anaphylaxis (IA) after administration of Pfizer BioNTech mRNA vaccine.

    Case Presentation: A 52-year-old man with recurrent episodes of IA after COVID-19 vaccination presented to our adult Allergy and Immunology Clinic. In the patient, urticaria and anaphylaxis episodes could not be controlled with high-dose antihistamine and systemic steroid treatment, and complete control was achieved with omalizumab treatment and anaphylaxis attacks completely regressed.

    Conclusion: In cases of unexplained or recurrent anaphylaxis in adult patients, COVID-19 vaccination and timing should be questioned, and its association with anaphylaxis might be considered.