DNA mismatch repair system expression in salivary gland tumors: a systematic review

• Geórgya Mayara Travasso Torres Alves ^[1] ; Raisa Jordana Geraldine Severino-Lazo ^[1] ; Gleyson Kleber do Amaral-Silva ^[2] ; Fabiana Moura da Motta Silveira ^[3] ; Marianne de Vasconcelos Carvalho ^[1]
  1. [1] Universidade de Pernambuco

     Universidade de Pernambuco

     Brasil

     
  2. [2] Universidade Federal de Mato Grosso do Sul

     Universidade Federal de Mato Grosso do Sul

     Brasil

     
  3. [3] Department of Oral Medicine, School of Health, Faculty Pernambucana of Health (FPS), Recife, Pernambuco, Brazil; Hospital Dentistry Center-Hospital Professor Fernando Figueira Institute of Integrative Medicine, Recife, Pernambuco, Brazil

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• Localización: Medicina oral, patología oral y cirugía bucal. Ed. inglesa, ISSN-e 1698-6946, Vol. 29, Nº. 5 (September), 2024
• Idioma: inglés
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• Resumen

  • The DNA mismatch repair (MMR) system serves as a sophisticated guardian of the precise functioning of the human genome. Dysregulation within this system is linked to the oncogenesis process. Reduced expression of MMR system proteins identified in salivary gland tumors (SGTs) suggests an increased risk of tumoral occurrence. This study aims to analyze the expression of MMR proteins in SGTs and discuss the relevance of this association to the development of these neoplasms.

    This review was conducted following the PRISMA guidelines and was registered in PROSPERO (CRD42023465590). A comprehensive search of the PubMed/MEDLINE, Web of Science, Scopus, Embase, and ProQuest (non-peer reviewed platform) was performed to answer the question “Do DNA MMR system proteins exhibit expression in SGTs?”. The methodological quality of the selected studies was assessed using the JBI’s Critical Appraisal Tool.

    A total of 142 patients with benign SGTs and 84 with malignant SGTs were included in this review. The literature analysis showed a noTable reduction in the expression of DNA MMR system proteins (hHMS2, hMLH1, hMSH3 and hMSH6) in the percentage of marked cells.

    The reduction in the expression of the DNA MMR system proteins suggests an interesting correlation with the development of malignant and benign SGTs. Nevertheless, further investigations are warranted to better clarify the precision of measuring biomarker protein expression.