Interesting New Findings of Retroperitoneal Fibrosis: Three Cases
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Pu Yuan [1] ; Xinwei Li [3] ; Yujie Yuan [2] ; Dongbin Jiang [1] ; Hui Wang [1] ; Peiyuan Xu [1] ; Dongkui Song [1]
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[1] First Affiliated Hospital of Zhengzhou University
First Affiliated Hospital of Zhengzhou University
China
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[2] Third Affiliated Hospital of Zhengzhou University
Third Affiliated Hospital of Zhengzhou University
China
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[3] Department of Clinical Medicine, Medical College of Zhengzhou University, 450000 Zhengzhou, Henan, China
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- Localización: Archivos españoles de urología, ISSN 0004-0614, Tomo 77, Nº. 7, 2024, págs. 818-825
- Idioma: español
- Texto completo no disponible (Saber más ...)
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Resumen
Objective: Retroperitoneal fibrosis is a rare disease characterized by chronic inflammation and fibrosis in the retroperitoneal space that may wrap around the ureter and cause an obstruction. Here we present the cases of three patients diagnosed and treated between April and August 2022.
Case Presentation: Here we present three cases of retroperitoneal fibrosis. Imaging revealed hydronephrosis and/or ureteral dilation, whereas laboratory findings such as erythrocyte sedimentation rate, C-reactive protein, and immunoglobulin G4 were abnormal. Serum creatinine and blood urea nitrogen levels suggested renal injury. Additionally, two patients had unclear diagnoses from other hospitals. Later, all patients underwent ureteral stenting and laparoscopic ureterolysis at our hospital and simultaneous diagnosis by biopsy. The two patients with high immunoglobulin G4 levels exhibited extremely severe fibrosis. After discharge, each received maintenance prednisone to prevent recurrence as well as methotrexate, followed by follow-up every 3 months. Fortunately, serum creatinine, blood urea nitrogen, and intravenous urography findings remained normal with an average follow-up of 8.5 months.
Conclusion: Here we discovered interesting findings in the diagnosis and treatment of retroperitoneal fibrosis, including the stable effect of medical plus surgical treatment, an unclear ureteral obstruction etiology, and the relationship between immunoglobulin G4 level and fibrosis hardness. However, the mechanisms behind these new findings require further study.
