Assessing clinical pathological characteristics and gene expression patterns associated with hepatoid adenocarcinoma of the stomach

• Dong Feng Ge ^[1] ; Yang Kun Wang ^[3] ; Ying Ying Li ^[4] ; Su Nan Wang ^[4] ; Xing Hai Liao ^[2] ; Chao Ya Zhu ^[5] ; Bo Jiang ^[6]
  1. [1] First Affiliated Hospital of Henan University of Science and Technology

     First Affiliated Hospital of Henan University of Science and Technology

     China

     
  2. [2] Southern Medical University

     Southern Medical University

     China

     
  3. [3] Department of Pathology, The Fourth People’s Hospital of , Longgang District, Shenzhen 518000, Guangdong Province, China
  4. [4] Shenzhen Polytechnic University, Shenzhen 518000, Guangdong Province, China
  5. [5] Department of Pathology, Third Affiliated Hospital, Zhengzhou University, Zhengzhou 450052, Henan Province, China
  6. [6] Department of Pathology, PLA Joint Logistics Support Force, No. 990 Hospital, Zhumadian 463000, Henan Province, China

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• Localización: Clinical & translational oncology, ISSN 1699-048X, Vol. 26, Nº. 10, 2024, págs. 2674-2684
• Idioma: inglés
• Texto completo no disponible (Saber más ...)
• Resumen

  • Objective The objective of this study is to assess the clinical pathological attributes of Hepatoid Adenocarcinoma of the Stomach (HAS) and to delineate the differential diagnostic considerations about it.

    Method The investigation involved analyzing 31 HAS cases using histomorphological assessment, immunohistochemical profiling, and relevant gene detection methodologies.

    Results Among the 31 HAS cases, 9 (29.0%) were of trabecular hepatoid adenocarcinoma of the stomach, 7 (22.6%) were of glandular hepatoid adenocarcinoma of the stomach, 4 (12.9%) were of nesting hepatoid adenocarcinoma of the stomach, 3 (9.7%) were of clear cell hepatoid adenocarcinoma of the stomach, and 8 (25.8%) were of diverse hepatoid adenocarcinoma of the stomach. Of these 31 cases, 24 were male, accounting for 77.4% of the cases. Serum alpha-fetoprotein (AFP) levels were notably elevated, with radioimmunoassay results reaching 1240 ng/ml; 28 out of 31 cases had AFP levels below 25 μg/l, accounting for 90.3%. Related genes: HER2 protein indicated positive expression on the cell membrane in 35.5% (11/31) of the cases; HER2 gene amplification detected by the FISH technique was 12.9% (4/31). Tumoral stromal lymphocytes exhibited a PD-1 positive expression rate of 58.1% (18/31). In gastric cancer tissues, the PD-L1 positive rate was 45.1% (14/31).

    Conclusion HAS represents a distinctive subtype of gastric cancer with a propensity for mimicking other forms of tumors, underscoring the significance of discerning its unique histopathological attributes for accurate differential diagnosis and tailored therapeutic interventions.