Heterogeneity and interplay: the multifaceted role of cancer‑associated fibroblasts in the tumor and therapeutic strategies
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Qiaoqiao Liu [1] ; Fei Yao [1] ; Liangliang Wu [1] ; Tianyuan Xu [1] ; Jintong Na [1] ; Zhen Shen [1] ; Xiyu Liu [1] ; Wei Shi [1] ; Yongxiang Zhao [1] ; Yuan Liao [1]
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[1] State Key Laboratory of Targeting Oncology, National Center for International Research of Bio‑Targeting Theranostics, Guangxi Key Laboratory of Bio‑Targeting Theranostics, Collaborative Innovation Center for Targeting Tumor Diagnosis and Therapy, Guangxi Medical University, Nanning 530021, China
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- Localización: Clinical & translational oncology, ISSN 1699-048X, Vol. 26, Nº. 10, 2024, págs. 2395-2417
- Idioma: inglés
- Texto completo no disponible (Saber más ...)
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Resumen
The journey of cancer development is a multifaceted and staged process. The array of treatments available for cancer varies significantly, dictated by the disease's type and stage. Cancer-associated fibroblasts (CAFs), prevalent across various cancer types and stages, play a pivotal role in tumor genesis, progression, metastasis, and drug resistance. The strategy of concurrently targeting cancer cells and CAFs holds great promise in cancer therapy. In this review, we focus intently on CAFs, delving into their critical role in cancer's progression. We begin by exploring the origins, classification, and surface markers of CAFs. Following this, we emphasize the key cytokines and signaling pathways involved in the interplay between cancer cells and CAFs and their influence on the tumor immune microenvironment. Additionally, we examine current therapeutic approaches targeting CAFs. This article underscores the multifarious roles of CAFs within the tumor microenvironment and their potential applications in cancer treatment, highlighting their importance as key targets in overcoming drug resistance and enhancing the efficacy of tumor therapies.
