Fertility preservation in hematological cancer patients
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Dan Li [1] ; Yi jun Zhao [1] ; Qian Wang [1] ; Man wei Chu [1] ; Juan ke Xie [1] ; Cui lian Zhang [1]
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[1] Zhengzhou University
Zhengzhou University
China
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- Localización: Clinical & translational oncology, ISSN 1699-048X, Vol. 26, Nº. 8, 2024, págs. 1836-1843
- Idioma: inglés
- Texto completo no disponible (Saber más ...)
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Resumen
Among adolescents and young adults, hematological malignancies are the most common malignancies. Although the survival rate of hematological malignancies in young patients has been dramatically improved, due to the continuous improvement and development of tumor diagnosis and treatment options, cytotoxic therapies can significantly reduce a patient’s reproductive capacity and cause irreversible infertility. The most two established solutions are embryo cryopreservation and oocyte cryopreservation which can be considered in single female. Sperm or testicular tissue cryopreservation in adult male are feasible approaches that must be considered before gonadotoxic therapy. A comprehensive consultation with reproductive specialists when once diagnosed is a significantly issue which would help those survivors who want to have children. In this article, we review germ cell toxicity, which happens during the treatment of hematological malignancies, and aims to propose safety, efficacy fertility preservation methods in younger patients with hematological malignancies.
