Insights into incipient oral squamous cell carcinoma: a comprehensive south-american study

• Cristina Saldivia-Siracusa ^[1] ; Anna Luíza Damaceno Araújo ^[2] ; Lady Paola Aristizabal Arboleda ^[8] ; Thamiris Abrantes ^[3] ; Mariana Bitu Ramos Pinto ^[9] ; Nathalia Mendonça ^[9] ; Karina Cordero-Torres ^[4] ; Gerardo Gilligan ^[5] ; Eduardo Piemonte ^[5] ; Rene Panico ^[5] ; Fábio De-Abreu-Álves ^[10] ; Mariana Villaroel-Dorrego ^[6] ; Mário José Romañach ^[3] ; Aline Corrêa Abrahão ^[3] ; Wilfredo Alejandro González-Arriagada ^[11] ; Keith D Hunter ^[7] ; Ana Carolina Prado Ribeiro ^[1] ; Marcio Ajudarte Lopes ^[1] ; Pablo Agustin Vargas ^[1] ; Alan Roger Santos-Silva ^[1]
  1. [1] Universidade Estadual de Campinas

     Universidade Estadual de Campinas

     Brasil

     
  2. [2] Universidade de São Paulo

     Universidade de São Paulo

     Brasil

     
  3. [3] Universidade Federal do Rio de Janeiro

     Universidade Federal do Rio de Janeiro

     Brasil

     
  4. [4] Universidad de Valparaíso

     Universidad de Valparaíso

     Valparaíso, Chile

     
  5. [5] Universidad Nacional de Córdoba

     Universidad Nacional de Córdoba

     Argentina

     
  6. [6] Universidad Central de Venezuela

     Universidad Central de Venezuela

     Venezuela

     
  7. [7] University of Liverpool

     University of Liverpool

     Reino Unido

     
  8. [8] DDS PhD, Graduate Program of A.C. Camargo Cancer Center, São Paulo, Brazil
  9. [9] DDS MSc, Semiology Department, AC Camargo Cancer Center Hospital (ACCC), São Paulo, Brazil
  10. [10] DDS PhD, Semiology Department, AC Camargo Cancer Center Hospital (ACCC), São Paulo, Brazil
  11. [11] 1DDS PhD, Oral Pathology Department, Faculty of Dentistry, University of Los Andes, Santiago de Chile, Chile

  Mostrar afiliaciones +
• Localización: Medicina oral, patología oral y cirugía bucal. Ed. inglesa, ISSN-e 1698-6946, Vol. 29, Nº. 4 (July), 2024
• Idioma: inglés
• Enlaces
  • Texto completo
• Resumen

  • To describe demographic and clinicopathological aspects of a South-American cohort of incipient oral squamous cell carcinoma patients.

    A cross-sectional, observational study was performed to assess demographic and clinicopathological characteristics of incipient oral squamous cell carcinoma patients from 6 South-American institutions.

    One hundred and seven patients within the histopathological spectrum of incipient oral squamous cell carcinoma (in-situ and microinvasive) were included. Fifty-eight (54.2%) patients were men with a mean age of 60.69 years. Forty-nine (45.8%) and thirty-nine (36.5%) patients had history of tobacco and alcohol use, respectively. Clinically, most of the lesions were plaques (82.2%), ≥ 2 cm in extension (72%), affecting the lateral border of the tongue (55.1%), and soft palate (12.1%) with a mixed (white and red) appearance. Eighty-two (76.7%) lesions were predominantly white and 25 (23.3%) predominantly red.

    To the best of our knowledge, this is the largest cohort of incipient oral squamous cell carcinoma patients, which raises awareness of clinicians’ inspection acuteness by demonstrating the most frequent clinical aspects of this disease, potentially improving oral cancer secondary prevention strategies.