Pharmacovigilance in Neuroscience: Farmacovigilancia en neurociencia

• Sánchez-de-Paz, María-Pilar ^[2] ; Da-Prat-de-Magalhaes, Gustavo ^[2] ; Isa, Santiago ^[2] ; Aldinio, Victoria ^[2] ; Norberto-Latella, Andres ^[1] ; Mabel-Gatto, Emilia ^[2] ; Rojas, Galeno J. ^[3]
  1. [1] Universidad de Buenos Aires

     Universidad de Buenos Aires

     Argentina

     
  2. [2] Sanatorio de la Trinidad Mitre
  3. [3] Sanatorio de la Trinidad Mitre/Universidad de Buenos Aires

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• Localización: Journal of Applied Cognitive Neuroscience (JACN), ISSN-e 2745-0031, Vol. 2, Nº. 1, 2021 (Ejemplar dedicado a: Journal of Applied Cognitive Neuroscience; e00143322)
• Idioma: inglés
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  • Background: Adverse drug reactions (ADRs) have a high impact on morbidity and mortality of the population, becoming a public health issue. Studying and publishing about these is referred as pharmacovigilance.Objective: To describe and compare the adverse reactions produced by drugs of nervous system action (CNS-D) and neurological ADRs produced by drugs of systemic action (Sys-D). To further develop the need of reporting adverse reactions. Methods: An observational, cross-sectional, retrospective study performed on a database of neurological consultations which took place at the Neurology department. Patients meeting the inclusion criteria were selected and divided into two groups: Sys-D and CNS-D. Demographic and neurological variables were analyzed. Parametric and non-parametric statistics were used according to distribution. The Naranjo Algorithm (NA) was used to define causality.Results: 71 ADRs were described, from which 63.38% (n=45) were produced by CNS-D, especially antiepileptics by 47% (n=21) and psycholeptics by 44%. Of the total, 36.62% (n=26) were caused by Sys-D, such as antineoplastics (n=9) and antibiotics (n=9), being Cefepime the most frequent. The diagnosis of ADRs caused by a Sys-D was delayed prolonging hospitalization (p 0.05) due to a lower NA score (p 0.003) compared to the CNS-D group.Conclusion: Multiple frequently used drugs of systemic action, such as antineoplastics and antibiotics, generate neurological adverse effects. From our analysis, it was presumed that the suspicion of a neurological ADR caused by these drugs was scarce, thus causing a higher morbidity for the patient.