Antidiarrhoeal activities of aqueous and methanolic extracts of Mangifera indica Linn stem bark (Anarcadiaceae) in wistar rats
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S. L. Wansi Ngnokam [1] ; L. M. Tchoumba Tchoumi [1]
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[1] Universite De Dschang
Universite De Dschang
Camerún
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- Localización: 1st Congress Bridge to Africa: Las Palmas de Gran Canaria, 20-25.02.2024, 2024, ISBN 9788490425275, págs. 118-129
- Idioma: español
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Resumen
Diarrhea is one of the leading causes of infant mortality in develop-ing country. It has been reported that Mangifera indica (Mi) is usedas an antidiarrhoeal agent in traditional medicine. This study wasto evaluate the antidiarrhoeal activities of aqueous and methanolicextracts of Mi Linn stem bark. The extracts were tested in vivo atdoses of 300, 400 and 500 mg/kg on the effects of Escherichiacoli, castor oil, misoprostol and charcoal meal in rats. In vivo, aqueous extract at doses of 300 and 500 mg/kg and methanolic ex-tract at dose of 500 mg/kg resulted in a significant decrease (p <0.001) in the bacterial load in rats faeces. A significant reduction(p < 0.001) of diarrhoeal parameters was observed with both ex-tracts after castor oil administration. The gut motility was signifi-cantly (p < 0.05) reduced with all doses of methanolic extract. Histopathological analysis revealed few abnormalities in structure andmorphology of the ileum after treatment of rats with aqueous andmethanolic extract This study showed that Mi possesses antidiarrheic properties and attest its usefulness in traditional treatment ofgastrointestinal infection.
