Update on the management of older patients with pancreatic adenocarcinoma: a perspective from medical oncology

• Mónica Guillot Morales ^[1] ; Laura Visa ^[2] ; Elena Brozos Vázquez ^[3] ; Jaime Feliu Batlle ^[4] ; Parham Khosravi Shahi ^[5] ; Berta Laquente Sáez ^[6] ; Borja López de San Vicente Hernández ^[7] ; Teresa Macarulla ^[8] ; Regina Gironés Sarrió ^[9]
  1. [1] Spanish Society of Medical Oncology (SEOM) Oncogeriatrics Section, Department of Medical Oncology, Son Espases University Hospital, Carretera de Valldemossa, 79, Islas Baleares, 07120 Palma de Mallorca, Spain
  2. [2] Spanish Society of Medical Oncology (SEOM) Oncogeriatrics Section, Mar-Parc de Salut Mar Hospital, Barcelona, Spain
  3. [3] Spanish Society of Medical Oncology (SEOM) Oncogeriatrics Section, A Coruña University Clinical Hospital, A Coruña, Spain
  4. [4] Multidisciplinary Spanish Group of Digestive Cancer (GEMCAD), La Paz University Hospital, IDIPAZ, CIBERONC, Cathedra UAM-AMGEN, Madrid, Spain
  5. [5] Spanish Society of Medical Oncology (SEOM) Oncogeriatrics Section, Gregorio Marañón University Hospital, Madrid, Spain
  6. [6] Spanish Society of Medical Oncology (SEOM) Oncogeriatrics Section, ICO L´Hospitalet-IDIBELL, Barcelona, Spain
  7. [7] Spanish Society of Medical Oncology (SEOM) Oncogeriatrics Section, Basurto University Hospital, Bilbao, Spain
  8. [8] Spanish Cooperative Group for the Treatment of Digestive Tumours (TTD), Hebron University Hospital, Vall d, Barcelona, Spain
  9. [9] Spanish Society of Medical Oncology (SEOM), Polytechnic la Fe University Hospital, Valencia, Spain

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• Localización: Clinical & translational oncology, ISSN 1699-048X, Vol. 26, Nº. 7, 2024, págs. 1570-1583
• Idioma: inglés
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• Resumen

  • In the context of pancreatic cancer, surgical intervention is typically recommended for localized tumours, whereas chemotherapy is the preferred approach in the advanced and/or metastatic setting. However, pancreatic cancer is closely linked to ageing, with an average diagnosis at 72 years. Paradoxically, despite its increased occurrence among older individuals, this population is often underrepresented in clinical studies, complicating the decision-making process. Age alone should not determine the therapeutic strategy but, given the high comorbidity and mortality of this disease, a comprehensive geriatric assessment (CGA) is necessary to defne the best treatment, prevent toxicity, and optimize older patient care. In this review, a group of experts from the Oncogeriatrics Section of the Spanish Society of Medical Oncology (Sociedad Española de Oncología Médica, SEOM), the Spanish Cooperative Group for the Treatment of Digestive Tumours (Grupo Español de Tratamiento de los Tumores Digestivos, TTD), and the Multidisciplinary Spanish Group of Digestive Cancer (Grupo Español Multidisciplinar en Cáncer Digestivo, GEMCAD) have assessed the available scientifc evidence and propose a series of recommendations on the management and treatment of the older population with pancreatic cancer.