Resumen de Efecto diurético de la especie Salvia scutellarioides en ratas.

Jorge Hernán Ramírez, Mauricio Palacios, Oscar Gutiérrez Lesmes

• español

  Introducción. En la medicina tradicional colombiana se usa la infusión de toda la planta llamada ""mastranto"" u ""oreja de perro"" (Salvia scutellarioides) por sus efectos antihipertensivos y diuréticos. Hasta ahora no se han hecho estudios experimentales para validar los efectos reportados. Objetivos. Determinar el efecto de S. scutellarioides en la diuresis y concentración de electrolitos urinarios utilizando un modelo en ratas. Materiales y métodos. Veinticuatro ratas Sprague-Dawley machos fueron repartidas al azar en cuatro grupos homogéneos: el grupo 1 recibió solución salina normal; el grupo 2, furosemida (10 mg/kg), y los grupos 3 y 4, S. scutellarioides (1 g/kg y 2 g/kg, respectivamente). Todos los tratamientos se administraron en un volumen de 25 ml/kg de peso del animal. Las ratas se colocaron en una jaula metabólica durante seis horas, y se cuantificó la excreción urinaria y los electrolitos en orina. Resultados. La administración de S. scutellarioides en dosis de 1 y 2 g/kg produjo un aumento significativo de la diuresis comparado con la del grupo control (p

• English

  Introduction. In the Colombian traditional medicine, an infusion made of the entire plant Salvia scutellarioides (known locally as mastranto or oreja de perro (dog's ear)) is used for its antihypertensive and diuretic effects. However, experimental studies have never been done to validate the reported effects.Objective. In the current study, a rat model was used to determine the effect of S. scutellarioides on rat diuresis and urinary electrolytes concentration.Materials And Methods. Twenty-four male Sprague-Dawley rats were distributed in four groups: Group 1--normal saline solution, Group 2--furosemide (10 mg/kg), Groups 3 and 4 with S. scutellarioides infusion, 1 g/kg and 2 g/kg respectively. All treatments were administered in a volume of 25 ml/kg of rat weight. After treatment, the rats were placed in a metabolic cage for 6 hours. During this period, urinary excretion was monitored and quantified. At the end of 6 hours, the urinary electrolyte concentrations were measured.Results. The administration of S. scutellarioides at doses of 1 and 2 g/kg produced a significant increase in diuresis when compared to the control group (p < 0.01). The administration of S. scutellarioides at these doses also increased the urinary excretion of potassium and chloride.Conclusions. These results corroborate the apparent diuretic activity of S. scutellarioides described by traditional herbalists and possibly explains its reported antihypertensive effect. Further studies are required to determine the pharmacological and toxicological profile of the plant.