Exosomal noncoding RNAs as noninvasive biomarkers in bladder cancer: a diagnostic meta‑analysis

• Liming Zhao ^[1] ; Jun Li ^[1] ; Zhongguang Xue ^[1] ; Jinfeng Wang ^[1]
  1. [1] Department of Nuclear Medicine, Linyi People’s Hospital, Shandong University, 27 Jiefang Road, Linyi 276003, Shandong, People’s Republic of China
• Localización: Clinical & translational oncology, ISSN 1699-048X, Vol. 26, Nº. 6, 2024, págs. 1497-1507
• Idioma: inglés
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• Resumen

  • Background In view of discordance consisting in diferent reports, a meta-analysis was conducted to comprehensively evaluate the diagnostic efcacy of exosomal noncoding RNAs (ncRNAs) in blood and urine in the detection of bladder cancer.

    Methods Eligible studies were acquired by systematic retrieval through PubMed, Cochrane Library, and Embase. The pooled diagnostic efcacy was appraised by reckoning the area under the summary receiver operating characteristic (SROC) curve. The latent sources of heterogeneity were probed by subgroup analyses and meta-regression. STATA 12.0, Meta-DiSc 1.4, and RevMan 5.3 were applied to carry out all statistical analyses and plots.

    Results A total of 46 studies from 15 articles comprising 2622 controls and 3015 bladder cancer patients were included in our meta-analysis. Exosomal ncRNAs in blood and urine represented relatively satisfactory diagnostic efcacy in detecting bladder cancer, with a pooled sensitivity of 0.75, a specifcity of 0.79, and an area under the SROC curve (AUC) of 0.84. Exosomal microRNAs (miRNAs) exhibited better diagnostic value with a pooled AUC of 0.91 than that of exosomal long noncoding RNAs (lncRNAs). To some extent, the heterogeneity among studies was induced by exosomal ncRNA types (miRNA or lncRNA), exosomal ncRNA profling (single- or multiple-ncRNA), sample size, specimen types, and ethnicity.

    Conclusion Exosomal ncRNAs in blood and urine may play a vital role in diagnosing bladder cancer as prospective noninvasive biomarkers; nonetheless, their clinical performance needs to be confrmed by further massive proactive researches.