An in vivo model to study the anti-malaric capacity of plant extracts

• Misael Chinchilla ^[1] ; Olga M. Guerrero ; Gabriela Abarca ; Mariano Barrios ; Oscar Castro
  1. [1] Universidad de Costa Rica

     Universidad de Costa Rica

     Hospital, Costa Rica

     
• Localización: Revista de Biología Tropical, ISSN 0034-7744, Vol. 46, Nº. 1, 1998, págs. 35-39
• Idioma: inglés
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• Resumen

  • An in vivo model to study the antimalaric effect of plant extracts is described. White mice (25-30g body weight) are treated subcutaneously with 0.6ml of the diluted extract starting seven days before P. berghei infection; treatment continues until death or for 30 days. Simultaneously 0.2ml of the extract are applied per os starting three days before infection. In a test of the model, treated and non-treated animals differed in body weight, survival time, haematocrite, parasitemia development, and spleen or liver weight of recent dead or killed mice.