Resumen de Actividad gastrointestinal del extracto acuoso bruto de Quassia amara (Simarubaceae)

Beatriz Badilla, Tatiana Miranda, Gerardo Mora, Kattia Vargas

• español

  En este estudio se ha investigado el efecto del extracto acuoso bruto de Q. amara a nivel gastrointestinal utilizando varios modelos experimentales en animales. Los resultados muestran que este extracto a dosis de 500 y 1000 mg/kg produce un aumento del tránsito gastrointestinal y que es capaz de inhibir las lesiones inducidas por la indometacina, el alcohol y el estrés. Los animales tratados con dosis de 1000 mg/kg mostraron disminución de la acidez de los contenidos estomacales y de la actividad péptica y un incremento en la cantidad del moco protector de la mucosa.

• English

  The gastrointestinal activity of an aqueous extract of the dry wood of Quassia amara was investigated using animal models. Oral administration of the extract to mice produces an increase of gastrointestinal transit at doses of 500 and 1000 mg/kg. The antiulcerogenic activity was measured inducing ulcers on Sprague-Dowly rats with indomethacin or ethanol and by the induction of stress. The experimental group was treated orally with the extract, using doses of 250, 500 and 1000 mg/kg before inducing the ulcers. Animals treated orally with 0.5 ml of water and ranitidine (50 mg/kg) were used as controls. All the animals treated with the extract at doses of 500 and 1000 mg/kg showed important protection against ulcer generation. Piloric ligation was used to stablish the activity on total acidity, peptic activity, non-protein sulfhydryl groups, and mucus production. Animals treated with 1000 mg/kg showed a reduction on acidity and peptic activity. No activity was detected on mucus production and non-protein sulfhydryl groups at these dosis but with 1500 mg/kg they showed an increase non-protein sulfhydryl groups producction.