Bias induced during the estimation of quality-adjusted life-years

• Alexandra Welsh ^[1] ; Deborah A. Costain ^[1] ; Andrew C. Titman ^[1]
  1. [1] Lancaster University

     Lancaster University

     Lancaster, Reino Unido

     
• Localización: Proceedings of the 35th International Workshop on Statistical Modelling : July 20-24, 2020 Bilbao, Basque Country, Spain / Itziar Irigoien Garbizu (ed. lit.), Dae-Jin Lee (ed. lit.), Joaquín Martínez Minaya (ed. lit.), María Xosé Rodríguez Álvarez (ed. lit.), 2020, ISBN 978-84-1319-267-3, págs. 454-458
• Idioma: inglés
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• Resumen

  • Quality-adjusted life-years (QALYs) are a summary measure used to evaluate the e ectiveness of medical treatments in terms of both quality and length of life. One method used to estimate QALYs is the area under the timeutility curve (AUC). However, this approach may induce bias, due to its inability to capture the dependency between the quality of life measures and the survival time. A simulation study is conducted to assess the bias induced when estimating QALYs using the AUC method, using data including censored individuals and missing responses.