Toxoplasmose em coelhos: comparação do perfil bioquímico hepático com os achados patológicos em infecção pelo Toxoplasma gondii

• ALEXANDRE DIAS MUNHOZ ^[1] ; ALEXANDRE REGO SOUZA PINTO ^[1] ; GEORGE RÊGO ALBUQUERQUE ^[1] ; FRANCISCO CARLOS RODRIGUES DE OLIVEIRA ^[2] ; ZELSON GIACOMO LOSS ^[3] ; CARLOS WILSON GOMES LOPES ^[3]
  1. [1] IV/UFRuralRJ Parasitologia Veterinária
  2. [2] UENF CCTA
  3. [3] IV/UFRRJ Departamento de Medicina e Cirurgia

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• Localización: Parasitología latinoamericana, ISSN-e 0717-7712, ISSN 0717-7704, Vol. 57, Nº. 1-4, 2002, págs. 83-87
• Idioma: portugués
• Títulos paralelos:
  • TOXOPLASMOSIS IN RABBITS: PROFILE HEPATIC BIOCHEMISTRY AND ITS RELATIONSHIP WITH PATHOLOGICAL FOUND DUE TO Toxoplasma gondii
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  • To determine the hepatic profiles due to Toxoplasma gondii infection in rabbits, 15 animals were divided in three groups of five animals each. The first and second groups were inoculated subcutaneously with 10(6) and 10³ tachyzoites of T. gondii respectively, while the third was left as control. Blood samples were taken on days 0, 4, 8, e 11 after inoculation (DAI). Livers of each rabbit was analyzed in other to observed lesions. Hepathomegaly was observed in all of the infected groups, independently of the dose used, where was observed a significant increase of AST e ALT at 8th DAI. Tachyzoites were observed in all infected animals, and were reisolated in 90% of livers bioassed in mice. Histopathology was consisted by diffuse infiltration inflammatory, consisted mainly by lymphocytes at sinusoids e portal space. The increase of AST and ALT during acute toxoplasmosis in rabbits was justified by presence of tachyzoites in tissue smears associated with gross and histopathologic lesions