Trypanosoma rangeli infected mouse sera reactivity with Trypanosoma cruzi synthetic peptides

• CLAUDIO ZUNIGA ^[1] ; RAMON VARGAS ^[1] ; MARIA TERESA PALAU ^[2] ; FELIO BELLO ^[4] ; JOSÉ ANTONIO DE DIEGO ^[3] ; ULISES VERGARA ^[1]
  1. [1] Universidad de Chile

     Universidad de Chile

     Santiago, Chile

     
  2. [2] Universidad La República

     Universidad La República

     Santiago, Chile

     
  3. [3] Universidad Autónoma de Madrid

     Universidad Autónoma de Madrid

     Madrid, España

     
  4. [4] Universidad de La Salle Depto.Ciencias Básicas

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• Localización: Parasitología latinoamericana, ISSN-e 0717-7712, ISSN 0717-7704, Vol. 62, Nº. 1-4, 2007, págs. 3-6
• Idioma: inglés
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• Resumen

  • In man, differential diagnosis of Trypanosoma cruzi and Trypanosoma rangeli infections represents a serious problem, not only because both parasites present similar geographical distribution, the same hosts and sometimes the same insect vector, but also because they have common antigen determinants. In this work IgM and IgG humoral responses to T. cruzi syntethic peptides in mice infected with T. cruzi and with T. rangeli were analysed. In a immunoradiometric assay (IRMA ) 6 syntethic peptides were used, denominated as clones 1, 2, SAPA, 13, 30 and 36. The results showed that sera from infected mice with T. rangeli recognized all peptides derived from T. cruzi proteins, at IgM as well as IgG level. Reactivity with peptide SAPA is discussed as previous work indicated that SAPA is not codified in the T. rangeli genome. Our results support the suggestion that crossed reactions are due to the fact that both parasites present common antigens