Associations of Maternal Educational Level, Proximity to Green Space During Pregnancy, and Gestational Diabetes With Body Mass Index From Infancy to Early Adulthood: A Proof-of-Concept Federated Analysis in 18 Birth Cohorts

• Autores: Tim Cadman, Ahmed Elhakeem, Johan Lerbech Vinther, Demetris Avraam, Paula Carrasco, Lucinda Calas, Marloes Cardol, Marie-Aline Charles, Eva Corpeleijn, Sarah E. Crozier, Montserrat de Castro, Marisa Estarlich, Amanda Fernandes, Serena Fossati, Dariusz Gruszfeld, Kathrin Guerlich, Veit Grote, Sido Haakma, Jennifer R. Harris, Barbara Heude, Rae-Chi Huang, Jesús Ibarluzea, Hazel Inskip, Vincent W.V. Jaddoe, Berthold Koletzko, Sandrine Lioret, Veronica Luque, Yannis Manios, Giovenale Moirano, George Moschonis, Johanna Nader, Mark J. Nieuwenhuijsen, Anne Marie Nybo Andersen, Rosie McEachan, Angela Pinot de Moira, Maja Popovic, Theano Roumeliotaki, Theodosia Salika, Loreto Santa Marina, Susana Santos, Sylvain Sebert, Evangelia Tzorovili, Marina Vafeiadi, Elvira Verduci, Martine Vrijheid, Tanja G. M. Vrijkotte, Marieke Welten, John Wright, Tiffany C Yang, Daniela Zugna, Deborah Lawlor
• Localización: American journal of epidemiology, ISSN-e 1476-6256, ISSN 0002-9262, Vol. 193, Nº. 5, 2024, págs. 753-763
• Idioma: inglés
• Texto completo no disponible (Saber más ...)
• Resumen

  • Abstract International sharing of cohort data for research is important and challenging. We explored the feasibility of multicohort federated analyses by examining associations between 3 pregnancy exposures (maternal education, exposure to green vegetation, and gestational diabetes) and offspring body mass index (BMI) from infancy to age 17 years. We used data from 18 cohorts (n = 206,180 mother-child pairs) from the EU Child Cohort Network and derived BMI at ages 0–1, 2–3, 4–7, 8–13, and 14–17 years. Associations were estimated using linear regression via 1-stage individual participant data meta-analysis using DataSHIELD. Associations between lower maternal education and higher child BMI emerged from age 4 and increased with age (difference in BMI z score comparing low with high education, at age 2–3 years = 0.03 (95% confidence interval (CI): 0.00, 0.05), at 4–7 years = 0.16 (95% CI: 0.14, 0.17), and at 8–13 years = 0.24 (95% CI: 0.22, 0.26)). Gestational diabetes was positively associated with BMI from age 8 years (BMI z score difference = 0.18, 95% CI: 0.12, 0.25) but not at younger ages; however, associations attenuated towards the null when restricted to cohorts that measured gestational diabetes via universal screening. Exposure to green vegetation was weakly associated with higher BMI up to age 1 year but not at older ages. Opportunities of cross-cohort federated analyses are discussed.