Mitochondrial Ca2+ homeostasis in health and disease

• Autores: Michelangelo Campanella, Paolo Pinton, Rosario Rizzuto
• Localización: Biological Research, ISSN-e 0717-6287, ISSN 0716-9760, Vol. 37, Nº. 4, 2004, págs. 653-660
• Idioma: inglés
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• Resumen

  • Although it has long been known that mitochondria possess a complex molecular repertoire for accumulating and releasing Ca2+, only in recent years has a large body of data demonstrated that these organelles promptly respond to Ca2+-mediated cell stimulations. In this contribution, we will review the principles of mitochondrial Ca2+ homeostasis and its signaling role in different physiological and pathological conditions.