Compensatory responses induced by oxidative stress in Alzheimer disease

• PAULA I MOREIRA ^[1] ; XIONGWEI ZHU ^[1] ; QUAN LIU ^[1] ; KAZUHIRO HONDA ^[1] ; SANDRA L SIEDLAK ^[1] ; PEGGY L HARRIS ^[1] ; MARK A. SMITH ^[1] ; GEORGE PERRY ^[1]
  1. [1] Case Western Reserve University

     Case Western Reserve University

     City of Cleveland, Estados Unidos

     
• Localización: Biological Research, ISSN-e 0717-6287, ISSN 0716-9760, Vol. 39, Nº. 1, 2006, págs. 7-13
• Idioma: inglés
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• Resumen

  • Oxidative stress occurs early in the progression of Alzheimer disease, significantly before the development of the pathologic hallmarks, neurofibrillary tangles and senile plaques. In the first stage of development of the disease, amyloid-β deposition and hyperphosphorylated tau function as compensatory responses and downstream adaptations to ensure that neuronal cells do not succumb to oxidative damage. These findings suggest that Alzheimer disease is associated with a novel balance in oxidant homeostasis.