Neuroanatomical basis of behavioral disturbances in patients with prefrontal lesions

• ANDREA SLACHEVSKY ^[1] ; MARCELA PEÑA ^[2] ; CAROLINA PÉREZ ^[3] ; EDUARDO BRAVO ^[4] ; PATRICIA ALEGRÍA ^[3]
  1. [1] Universidad de Chile

     Universidad de Chile

     Santiago, Chile

     
  2. [2] Pontificia Universidad Católica de Chile

     Pontificia Universidad Católica de Chile

     Santiago, Chile

     
  3. [3] El Salvador Hospital Department of Neurology
  4. [4] Asenjo Institute of Neurosurgery

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• Localización: Biological Research, ISSN-e 0717-6287, ISSN 0716-9760, Vol. 39, Nº. 2, 2006, págs. 237-250
• Idioma: inglés
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• Resumen

  • The role of the frontal lobe in control of behavioral and cognitive abilities is explored in a group of 34 patients with brain lesions restricted to the prefrontal cortex. The scores in both structured behavioral questionnaires and standard neuropsychological tests were analyzed using the injured area of the frontal lobe as the independent variable. Our results show that patients with simultaneous lesions in supero_ and inferomedial areas of the prefrontal cortex exhibit higher behavioral disturbances. Bilateral lesions also are associated with greater behavioral troubles. On the contrary, cognitive abilities are globally impaired in prefrontal patients. Results are discussed in relation to current models of the organization of the prefrontal cortex and its role on behavior control