The ingestión of a Nectandra membranácea extract changes the bioavailability of technetium-99m radiobiocomplex in rat organs

• SILVANA RAMOS FARÍAS MORENO ^[1] ; ADRIANO ARNOBIO ^[1] ; JORGE JOSÉ DE CARVALH0 ^[2] ; LUCIA NASCIMENT0 ^[2] ; MARGARETH OLIVEIRA TIMOTEO ^[1] ; BENI OLEJ ^[1] ; EMELY KAZAN ROCHA ^[2] ; MARIO PEREIRA ^[2] ; MARIO BERNARDO-FILH0 ^[2] ; LUIZ QUERINO DE ARAÚJO CALDAS ^[3]
  1. [1] Universidade Federal Fluminense

     Universidade Federal Fluminense

     Brasil

     
  2. [2] Universidade do Estado do Rio de Janeiro

     Universidade do Estado do Rio de Janeiro

     Brasil

     
  3. [3] Instituto Nacional do Cáncer Coordenadoria de Pesquisa

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• Localización: Biological Research, ISSN-e 0717-6287, ISSN 0716-9760, Vol. 40, Nº. 2, 2007, págs. 131-135
• Idioma: inglés
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• Resumen

  • The radiobiocomplexes labeled with technetium-99m (Tc-99m) have been widely used in nuclear medicine in single photon emission computed tomography and in basic research. The aim of this study was to assess the influence of a Nectandra membranácea extract on the bioavailability of the sodium pertechnetate (Na99mTc0(4)) radiobiocomplex in rat organs. The animals were treated with a N. membranácea extract (30 mg/ ml), for 6 days. Na99mTc0(4) was injected, the organs were isolated and weighed, and the radioactivity was determined in each organ (%ATI/organ). The %ATI/organ was divided by the mass of each organ to calculate the %ATI/g. A significant increase of the %ATI/organ of Na99mTc0(4) was observed in muscle and thyroid as well as in the %ATI/g in the heart, kidney and thyroid. These findings could result from the interaction between components of the plant extract and the radiobiocomplex which may influence the uptake Na99mTc0(4) in rat organs. Therefore, precaution is suggested in the interpretation of nuclear medicine results in patients using this herb