Toll-like Receptors are Key Participants in Innate Immune Responses
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SERGIO A ARANCIBIA [1] ; CAROLL J BELTRÁN [1] ; ISABEL M AGUIRRE [1] ; PAULINA SILVA [1] ; ALEXIS L PERALTA [1] ; FRANO MALINARICH [1] ; MARCELA A HERMOSO [1]
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[1] Universidad de Chile
Universidad de Chile
Santiago, Chile
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- Localización: Biological Research, ISSN-e 0717-6287, ISSN 0716-9760, Vol. 40, Nº. 2, 2007, págs. 97-112
- Idioma: inglés
- Enlaces
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Resumen
During an infection, one of the principal challenges for the host is to detect the pathogen and activate a rapid defensive response. The Toll-like family of receptors (TLRs), among other pattern recognition receptors (PRR), performs this detection process in vertebrate and invertebrate organisms. These type I transmembrane receptors identify microbial conserved structures or pathogen-associated molecular patterns (PAMPs). Recognition of microbial components by TLRs initiates signaling transduction pathways that induce gene expression. These gene products regulate innate immune responses and further develop an antigen-specific acquired immunity. TLR signaling pathways are regulated by intracellular adaptor molecules, such as MyD88, TIRAP/Mal, between others that provide specificity of individual TLR- mediated signaling pathways. TLR-mediated activation of innate immunity is involved not only in host defense against pathogens but also in immune disorders. The involvement of TLR-mediated pathways in auto-immune and inflammatory diseases is described in this review article
