Antioxidant, Antibacterial activity and Brine shrimp toxicity test of some Mountainous Lichens from Nepal

• Babita Paudel ^[1] ; Hari Datta Bhattarai ^[2] ; Durga Prasad Pandey ^[2] ; Jae Seoun Hur ^[3] ; Soon Gyu Hong ^[1] ; Il-Chan Kim ^[1] ; Joung Han Yim ^[1]
  1. [1] Korea Polar Research Institute Division of LifeSciences
  2. [2] Tribhuvan University Research Center for Applied Science and Biotechnology
  3. [3] Sunchon National University Korean Lichen Research Institute

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• Localización: Biological Research, ISSN-e 0717-6287, ISSN 0716-9760, Vol. 45, Nº. 4, 2012, págs. 387-391
• Idioma: inglés
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  • A total of twenty four lichen species belonging to six families were collected from mountainous region of Nepal. The methanol extracts of each species were tested for antimicrobial and antioxidant activitiesin vitro. It was found that extracts of twenty one lichen species were active againstB. subtilis and seven species were active againstS. aureus. Similarly, in DPPH assay, three speciesPeltigera sp.,Cladonia sp., andCanoparmelia sp. showed comparable activity with commercial standard, BHA. In ABTS+ assay, extracts ofParmoterma sp.,Ramalina sp.,Peltigera sp. andCladonia sp. showed stronger activity than ascorbic acid. The observed data after comparison with previously published reports indicated that the high altitude lichens contain stronger antioxidant and antibacterial constituents. Similarly, the methanol extracts ofHeterodermia sp. andRamalina sp. showed comparable toxicity effect with commercial standard berberine chloride indicating a potent source of anticancer drugs.