Anatomy of corpus callosum in prenatally malnourished rats

• Ricardo Olivares ^[1] ; Carlos Morgan ^[2] ; Hernán Pérez ^[2] ; Alejandro Hernández ^[3] ; Francisco Aboitiz ^[4] ; Rubén Soto-Moyano ^[2] ; Julio Gil ^[5] ; Alexis Ortiz ^[6] ; Osvaldo Flores ^[2] ; Miguel Gimeno ^[5] ; Jesús Laborda ^[5]
  1. [1] Universidad de Chile Facultad de Ciencias Veterinarias y Pecuarias Departamento de Ciencias Biológicas Animales
  2. [2] Universidad de Chile Instituto de Nutrición y Tecnología de los Alimentos Laboratorio de Nutrición y Regulación Metabólica
  3. [3] Universidad de Santiago Facultad de Química y Biología Departamento de Biología
  4. [4] Pontificia Universidad Católica de Chile Escuela de Medicina y Centro Interdisciplinario de Neurociencia Departamento de Psiquiatría
  5. [5] Universidad de Zaragoza Facultad de Veterinaria Departamento de Anatomía, Embriología y Genética Animal
  6. [6] Universidad Andrés Bello Facultad de Ecología y Recursos Naturales

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• Localización: Biological Research, ISSN-e 0717-6287, ISSN 0716-9760, Vol. 45, Nº. 1, 2012, págs. 87-92
• Idioma: inglés
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• Resumen

  • The effect of prenatal malnutrition on the anatomy of the corpus callosum was assessed in adult rats (45-52 days old). In the prenatally malnourished animals we observed a significant reduction of the corpus callosum total area, partial areas, and perimeter, as compared with normal animals. In addition, the splenium of corpus callosum (posterior fifth) showed a significant decrease of fiber diameters in the myelinated fibers without changing density. There was also a significant decrease in diameter and a significant increase in density of unmyelinated fibers. Measurements of perimeter's fractal dimensions from sagittal sections of the brain and corpus callosum did not show significant differences between malnourished and control animals. These findings indicate that cortico-cortical connections are vulnerable to the prenatal malnutrition, and suggest this may affect interhemispheric conduction velocity, particulary in visual connections (splenium).