Apoplejía en metástasis hipofisiaria de carcinoma de células renales: Caso clínico con siete años de seguimiento

• Autores: Iván Quevedo L, José A Rodríguez Portales, Helmar Rosenberg G, Jorge Mery S
• Localización: Revista Médica de Chile, ISSN-e 0034-9887, Vol. 128, Nº. 9, 2000, págs. 1015-1018
• Idioma: español
• Títulos paralelos:
  • Pituitary apoplexy secondary to a metastatic renal cell carcinoma: Report of a case followed for seven years
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• Resumen

  • We report a man in whom a 15 cm. renal tumor was excised at the age of 49. The pathological examination showed a clear cell carcinoma. Five years later, he presented with headache, vomiting and unilateral palpebral ptosis. Imaging studies showed a sellar tumor with pituitary apoplexy. The tumor was excised and the pathological study disclosed a clear cell tumor, positive for vimentin, cytokeratins AE1 and AE3 and immunohistochemically negative for LH, TSH, ACTH and GH. Considering the similar histopathological features, it was considered as a metastasis of the renal tumor. The patient was supplemented with thyroid, adrenal and gonadal hormones. Seven years later, he presented a new tumor in the remaining kidney, that corresponded to a cystic papillary renal cell carcinoma. Afterwards, he presented a transitional urinary bladder tumor. Mortality associated to renal cell tumors is 90% at 5 years, and pituitary metastases are extraordinarily uncommon (Rev Méd Chile 2000; 128: 1015-8).