Managing children with frequent respiratory infections and associated wheezing: a preliminary randomized study with a new multicomponent nasal spray

M. Tosca; Matteo Naso; Attilio Varricchio; Irene Schiavetti; Valerio Damiani; G. Ciprandi

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Managing children with frequent respiratory infections and associated wheezing: a preliminary randomized study with a new multicomponent nasal spray

Maria Angela Tosca ^[3] ; Matteo Naso ^[3] ; Attilio Varricchio ^[1] ; Irene Schiavetti ^[2] ; Valerio Damiani ^[4] ; Giorgio Ciprandi ^[5]
1. [1] University of Molise
  
  University of Molise
  
  Campobasso, Italia
2. [2] University of Genoa
  
  University of Genoa
  
  Genoa, Italia
3. [3] Allergy Center, IRCCS Istituto Giannina Gaslini, Genoa, Italy
4. [4] Medical Department, D.M.G., Pomezia, Italy
5. [5] Allergy Clinic, Casa di Cura Villa Montallegro, Genoa, Italy
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Localización: Allergologia et immunopathologia: International journal for clinical and investigate allergology and clinical immunology, ISSN-e 1578-1267, ISSN 0301-0546, Vol. 52, Nº. 3, 2024, págs. 22-30
Idioma: inglés
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Resumen
- Background: Preschoolers frequently have respiratory infections (RIs), which may cause wheezing in some subjects. Type 2 polarization may favor increased susceptibility to RIs and associated wheezing. Non-pharmacological remedies are garnering increasing interest as possible add-on therapies. The present preliminary study investigated the efficacy and safety of a new multi-component nasal spray in preschoolers with frequent RIs and associated wheezing.
  
  Methods: Some preschoolers with these characteristics randomly took this product, containing lactoferrin, dipotassium glycyrrhizinate, carboxymethyl-beta-glucan, and vitamins C and D3 (Saflovir), two sprays per nostril twice daily for 3 months. Other children were randomly treated only with standard therapy. Outcomes included the number of RIs and wheezing episodes, use of medications, and severity of clinical manifestations.
  
  Results: Preschoolers treated add-on with this multicomponent product experienced fewer RIs and used fewer beta-2 agonists than untreated children (P = 0.01 and 0.029, respectively).
  
  Conclusions: This preliminary study demonstrated that a multicomponent product, administered add-on as a nasal spray, could reduce the incidence of RIs and use of symptomatic drugs for relieving wheezing in children.