Linfoma intravascular tratado con anticuerpos monoclonales anti CD20: Descripción de un caso clínico
-
Jorge Alfaro L [1] ; Arturo Espinoza N [2] ; María Manríquez A [2] ; Leonor Moyano [1] ; Néstor González G [1] ; Milton Larrondo L [1] ; Gastón Figueroa M [1]
-
[1] Universidad de Chile
Universidad de Chile
Santiago, Chile
-
[2] Clínica Dávila Servicio de Oncología Anatomía Patológica
-
- Localización: Revista Médica de Chile, ISSN-e 0034-9887, Vol. 132, Nº. 11, 2004, págs. 1403-1406
- Idioma: español
- Títulos paralelos:
- Intravascular lymphoma treated with anti CD20 monoclonal antibodies: Report of one case
- Enlaces
-
Resumen
We report a 78 year old male with prostatism, that was subjected to a prostate biopsy. The pathological study showed a microvascular lymphocytic infiltration. Four months later, the patients presentd with reduced alertness, cough, dyspnea, fever and elevation of lactic dehydrogenase and erythrocyte sedimentation rate. Chest and abdominal CAT scans, bone marrow aspirate, protein electrophoresis and prostate specific antigen were normal. A re-evaluation of prostate biopsy showed an intravascular lymphoid infiltration, positive for CD45 and CD20, compatible with the diagnosis of intravascular lymphoma. Chemotherapy was started, but it was not tolerated by the patient and the response was partial. Therefore, treatment with monoclonal antibodies anti CD20 (Rituximab) was started. The tumor had a complete and prolonged (24 months) remission after the treatment
