"Hierba del Clavo" (Geum chiloense) interfiere niveles de ciclosporina: Potencial riesgo para trasplantados

• Autores: Jaime Duclos H, Helmuth Goecke
• Localización: Revista Médica de Chile, ISSN-e 0034-9887, Vol. 129, Nº. 7, 2001, págs. 789-790
• Idioma: español
• Títulos paralelos:
  • Geum chiloense (Hierba del clavo) modifying cyclosporine levels.: Report of one case
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• Resumen

  • We report a 54 years old male that received a renal allograft without complications. One year after the transplantation, she was receiving cyclosporine doses of 2 to 3 mg/kg and maintained serum levels of 60 to 90 mg/dl. An abrupt increase in cyclosporine serum levels to 469 and 600 mg/dl was noted after 15 months of transplantation. After a careful interrogation the patient admitted the use of Geum chiloense ("hierba del clavo"). Discontinuing this herbal remedy, cyclosporine levels decreased to 55 mg/dl, despite the maintenance of the same cyclosporine dose. The potential side effects of herbal remedies must be borne in mind (Rev Méd Chile 2001; 129: 789-90).