Infecciones sistémicas por levaduras en un hospital general: Correlación entre estudio de susceptibilidad in vitro y supervivencia de los pacientes al episodio de infección fúngica
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Cecilia Tapia P [1] ; Patricia González A ; MC Díaz J ; Valerie Corvalán N ; Marcela Gaete F ; Manuel Cuenca-Estrella ; JL Rodríguez-Tudela
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[1] Hospital Dr. Sótero del Río
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- Localización: Revista Médica de Chile, ISSN-e 0034-9887, Vol. 130, Nº. 6, 2002, págs. 661-665
- Idioma: español
- Títulos paralelos:
- Systemic yeast infections in a General Hospital: susceptibility and patient survival
- Enlaces
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Resumen
Background: Fungi are important causal agents of nosocomial infections, that usually have high mortality rates. Aim: To evaluate the species distribution and susceptibility patterns of deep yeast infections in a General Hospital and to correlate those results with patient survival. Material and methods: Twenty one strains (from five pediatric and 16 from adult patients) were studied. Antifungal Susceptibility Testing (AST) to Amphotericin B (Anfb), Fluorocytosine (5FC), Fluconazole (FZ) and Itraconazole (IZ) was performed according to the EUCAST document. Clinical data of patients was obtained and survival to the infection was recorded. Results: C. albicans was isolated in 11 samples (52%), C. parapsilosis in three samples (14%), C. glabrata in two samples (9%), C. tropicalis in one sample (5%) and C. neoformans in four samples (19%). Twenty three percent of fungi were recovered at the Surgical Intensive Care Unit. The MICs ranged between 0.25 and 0.5 µg/mL for Anfb; between 0.25 and 16 µg/ml for SFC, between 0.12 and 32 µg/mL for FZ and 0.015 and 0.5 µg/mL for IZ. No association between antifungal susceptibility and patient survival was observed. Conclusions: C. albicans continues to be the most frequently isolated yeast, however, non-albicans species are an emergent group causing nosocomial infections. Surgical procedures are the main source of fungal infections in this sample (Rev Méd Chile 2002; 130: 661-65)
