Anticuerpos anti-albúmina bovina (BSA) en niños diabéticos tipo 1 recién diagnosticados y su asociación con lactancia materna y exposición a leche de vaca

• Amaya Oyarzún A ^[1] ; J Luis Santos M ^[1] ; Elena Carrasco P ^[3] ; Cecilia Albala B ^[1] ; Alfonso Salinas T ^[2] ; Francisco Pérez B ^[1]
  1. [1] Universidad de Chile

     Universidad de Chile

     Santiago, Chile

     
  2. [2] Universidad de Santiago de Chile

     Universidad de Santiago de Chile

     Santiago, Chile

     
  3. [3] Universidad de Chile Facultad de Medicina Hospital San Juan de Dios

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• Localización: Revista Médica de Chile, ISSN-e 0034-9887, Vol. 131, Nº. 8, 2003, págs. 865-872
• Idioma: español
• Títulos paralelos:
  • Bovine serum albumin (BSA) antibodies in children with recently diagnosed type 1 diabetes
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• Resumen

  • Background : Environmental and genetic factors (viruses, toxins and diet) are involved in the aetiology of type 1 diabetes. Among the dietary factors, the role of breast feeding and exposure to cow's milk proteins deserve special attention. Aim: To determine the anti-BSA-IgG levels in type 1 diabetic children and to analyse the possible association with breast feeding duration, exposure to cow's milk and ß pancreatic auto-antibodies. Patients and methods: Blood samples were collected from 161 diabetic children and 144 controls to measure anti-BSA-IgG level, GAD65, IA-2 and ICA autoantibodies. All children answered a questionnaire about dietary habits during infancy. Results: anti-BSA-IgG was positive (using a cut off point of 25.6 ng/ml) in 98% of diabetic children and 0% of the control population. The length of breast feeding or early exposure to cow's milk did not influence the concentration of anti-BSA-IgG. Positive BSA titers did not increase the ß pancreatic reactivity (ICA+, GAD+, IA-2+). Conclusions: Our data confirm the high frequency of anti-BSA-IgG among diabetic children. However, a specific role in the immunological process of type 1 diabetes cannot be attributed to this protein (Rev Méd Chile 2003; 131: 865-72)