Interacciones genéticas y genético-ambientales como efecto modificador del riesgo de cáncer de próstata: un diseño «case-only»

• Dante Cáceres L ^[1] ; Jeannette Iturrieta G ^[1] ; Cristian Acevedo C ^[2] ; Christian Huidobro A ^[2] ; Nelson Varela F ^[1] ; Mario Escala Z ^[1] ; Luis Quiñones S ^[1]
  1. [1] Universidad de Chile

     Universidad de Chile

     Santiago, Chile

     
  2. [2] Corporación Nacional del Cáncer
• Localización: Revista Médica de Chile, ISSN-e 0034-9887, Vol. 132, Nº. 8, 2004, págs. 961-970
• Idioma: español
• Títulos paralelos:
  • Gene-gene and gene-environment interactions as modifier factors of prostatic cancer risk: «a case-only» design study
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• Resumen

  • Background: The role of susceptibility low penetrance genes and environmental factors in the etiology of prostate cancer (PCa) is unclear, but may involve in some cases multiple alleles at multiple loci. Aim: To evaluate the association of gene-gene and gene-environment interactions with PCa. Patients and methods: One hundred three subjects with biopsy proven PCa were studied, using a case-only design. All were interrogated about smoking habits. Polymorphisms for Glutathione-S-transferase (GST) and Cytochrome P4501A1 (CYP1A1), were measured in DNA extracted from peripheral Iymphocytes, using a restriction fragment length polymorphism analysis. Results: Our findings suggest that gene-gene interactions between GSTT1 and CYP1A1 high risk genotypes were positive modifiers and had a high predictive value for the presence of PCa, compared with non-susceptibility genotypes. The interaction between susceptibility genotypes and smoking did not modify the risk for PCa. Conclusions: Gene-gene interactions may play a role modulating the susceptibility to PCa in a proportion of affected individuals (Rev Méd Chile 2004; 132: 961-66).