Síndrome neuroléptico maligno y poliserositis en paciente usuaria de clozapina: una asociación infrecuente

Gonzalo Eymin L ^[1] ; Max Andresen H ^[1] ; Jaime Godoy F ^[1] ; Gabriel Rada G ^[1]
1. [1] Pontificia Universidad Católica de Chile
  
  Pontificia Universidad Católica de Chile
  
  Santiago, Chile
Localización: Revista Médica de Chile, ISSN-e 0034-9887, Vol. 133, Nº. 10, 2005, págs. 1225-1228
Idioma: español
Títulos paralelos:
- Malignant neuroleptic syndrome and polyserositis associated to clozapine use: Report of one case
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Resumen
- Malignant neuroleptic syndrome is a complication of antipsychotic medication use. Clozapine use is also associated with polyserositis and eosinophilia. We report a 17 years old female treated with clozapine, valproic acid, lithium carbonate and lorazepam that consulted in the emergency room for confusion, lethargy, catatonia, rigidity, myalgya and fever. Complete blood count showed eosinophilia. An abdominal CAT scan showed ascites and pleural effusion. Clozapine was discontinued and bromocriptine was started. One week after admission, the patient remained febrile and liver enzymes were elevated. Valproic acid was discontinued. Inflammatory parameters stated to subside and the patient was discharged afebrile days after admission (Rev Méd Chile 2005; 133: 1225-8)