Retiro precoz de esteroides en la inmunosupresión del trasplante renal pediátrico

• Angela Delucchi B ^[2] ; Marcela Valenzuela A ^[3] ; Mario Ferrario B ^[2] ; Ana María Lillo D ^[2] ; José Luis Guerrero G ^[2] ; Eugenio Rodríguez S ^[2] ; Francisco Cano Sch ^[2] ; Gabriel Cavada Ch ^[1] ; Jorge Godoy L ^[2] ; Jorge Rodríguez H ^[2] ; Gloria González G ^[2] ; Erwin Buckel B ^[2] ; Luis Contreras M ^[1]
  1. [1] Universidad de Chile

     Universidad de Chile

     Santiago, Chile

     
  2. [2] Hospital Luis Calvo Mackenna Unidad de Nefrología y Trasplante Renal
  3. [3] Hospital Guillermo Grant Benavente Unidad de Nefrología y Trasplante Renal

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• Localización: Revista Médica de Chile, ISSN-e 0034-9887, Vol. 134, Nº. 11, 2006, págs. 1393-1401
• Idioma: español
• Títulos paralelos:
  • Early steroid withdrawal in pediatric renal transplantation
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  • Background: Cardiovascular risk, growth failure and the new immunosuppressive drugs, have encouraged steroid withdrawal or total avoidance with promising results in renal transplant (Tx) immunosuppression. Aim: To evaluate a new immunosuppressor protocol with early withdrawal of steroids in pediatric kidney transplant. Patients and methods: Prospective study in pediatric patients older than 1 year and low immunological risk. Group A (n =28): steroids in decreasing doses until day 7 post Tx, tacrolimus (FK) and micophenolate mofetil (MMF). Group B (n =28) control: steroids, cyclosporine and azathioprine or steroids, FK and MMF. In both groups the induction therapy included basiliximab. Anthropometric and biochemical variables (renal function, lipid profile, hematological, blood glucose and acid-base equilibrium), acute rejection and CMV infection, were evaluated. Mean values and variations for continuous variables were calculated at months 1, 6, 12 and 18. Results: Two children were withdrawn before month 2, one had an untreatable diarrhea and the second died due to Aspergillus septicemia. Mean values at months 1, 6, 12 and 18 for groups A and B: Creatinine clearence (ml/min): 85.4 vs 89; 79.9 vs 83; 89 vs 80; 79.8 vs 80.6 (p: ns); hematocrit (%): 28.8 vs 30.4; 31.7 vs 34.4; 34.4; 32.4 vs 34.8; 34.4 vs 35.5 (p: ns). Total cholesterol (mg/dl): 151 vs 206; 139 vs 174; 138 vs 186; 140 vs 180 (p <0.05). Mean delta height/age Z score at the first year: 0.5 vs 0.15; 0.7 vs 0.22; 0.97 vs 0.25 (p <0.05). Mean systolic blood pressure Z score: 0.9 vs 1.5; 0.5 vs 0.9; -0.3 vs 0.8; 0.1 vs 1.0 (p <0.05). The height/age Z score was significantly superior in patients without steroids. A normalization of growth patterns at month 18 was observed (< 0.05). Both groups presented a negative variation of creatinine clearance during the follow-up, but it was minor in the study group (p <0.05). Two acute rejections were found in each group, and no difference in CMV infections was observed. Conclusions: Early steroid withdrawal in pediatric renal transplant recipients was effective and safe and did not increase the risk of rejection