Frecuencia de los genes de fusión TEL/AML1 y BCR/ABL en pacientes pediátricos con leucemia linfoblástica aguda
-
Carmen Gloria Artigas A [3] ; María Elena Cabrera C [1] ; Angélica Melo A [2] ; Eduardo Páez F [2] ; Mónica Arriagada M [2] ; Carmen Astete A [4] ; Iván Roa E [3] ; Juan Carlos Roa S [2]
-
[1] Hospital del Salvador
Hospital del Salvador
Santiago, Chile
-
[2] Universidad de La Frontera
Universidad de La Frontera
Temuco, Chile
-
[3] Clínica Alemana de Temuco Departamento Anatomía Patológica Banco de Tumores Temuco
-
[4] Hospital Luis Calvo Mackenna Laboratorio de Citogenética
-
- Localización: Revista Médica de Chile, ISSN-e 0034-9887, Vol. 134, Nº. 11, 2006, págs. 1367-1376
- Idioma: español
- Títulos paralelos:
- Frequency of TEL/AML1 and BCR/ABL fusion genes in children with acute lymphoblastic leukemia
- Enlaces
-
Resumen
Background: t(12;21) (p12;q22) and t(9;22) (q34;q11) translocations have prognostic significance in acute lymphoblastic leukemia (ALL). The fusion genes TEL/AML1 y BCR/ABL, generated by these translocations, can be easily detected using molecular biology technique. Aim: To study the frequency of TEL/AML1 y BCR/ABL fusion genes in children with ALL. Material and methods: Fifity six children with ALL (age range 1 month- 14 years) were studied, thirty eight from our Temuco Hospital and 18 from the Metropolitan Region. TEL/AML1 y BCR/ABL fusion genes were detected in bone marrow samples using a reverse transcriptase nested polymerase chain reaction (RT-PCR). Results: TEL/AML 1 and BCR/ABL fusion gene transcripts were detected in 13 (23%) and 2 (4%) children, respectively. No differences in survival were observed between children with positive or negative transcripts for TEL/AML1 fusion gene. However, those positive for BCR/ABL fusion gene, had a significantly lower survival. Conclusions: The frequency of TEL/AML1 and BCR/ABL fusion gene transcripts in these children with ALL is similar to that described by other authors
