Determinación de factores trombofílicos en pacientes con trombosis venosas retinianas

L. Traipe-Castro; Guillermo Conte L; Francisco J Conte S; Santiago Ibáñez L; Patricio Meza R; Basilio Rojas U; Marianela Cuneo V; Juan Verdaguer

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Determinación de factores trombofílicos en pacientes con trombosis venosas retinianas

Leonidas Traipe C ^[1] ; Guillermo Conte L ^[1] ; Francisco J Conte S ^[2] ; Santiago Ibáñez L ^[2] ; Patricio Meza R ^[1] ; Basilio Rojas U ^[2] ; Marianela Cuneo V ^[1] ; Juan Verdaguer T ^[2]
1. [1] Universidad de Chile
  
  Universidad de Chile
  
  Santiago, Chile
2. [2] Fundación Oftalmológica Los Andes
Localización: Revista Médica de Chile, ISSN-e 0034-9887, Vol. 133, Nº. 2, 2005, págs. 167-174
Idioma: español
Títulos paralelos:
- Markers of thrombophilia in patients with retinal vein thrombosis
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Resumen
- Background: Thrombophilia is an alteration of hemostasis that increases the risk to venous or arterial thrombosis. This condition may be the underlying cause of retinal vein thrombosis. Aim: To study the presence of thrombophilia in patients with retinal vein thrombosis. Patients and methods: Prospective study of 55 patients aged 22 to 86 years, with retinal vein thrombosis (central or branch). Antithrombin III, coagulant protein C, functional protein S, resistance to activated C protein, homocysteine, prothrombin G20210A gene, lupus anticoagulant and anticardiolipin antibodies were measured in all. Results: Seventeen patients had thrombophilic markers (antiphospholipid syndrome in seven, hyperhomocysteinemia in six and resistance to protein C in three). Of these 17 patients, 53% had high blood pressure, 35% an abnormal serum lipid profile and 23% a personal history of thrombosis. The thrombosis was central in 12 (ischemic in four) and of a branch in five (ischemic in two). Conclusions: Thrombophilic markers must be assessed in patients with retinal vein thrombosis (Rev Méd Chile 2005; 133: 167-74)