Resumen de A Histone H2A Derived Antimicrobial Peptide from the Blue Swimmer Crab, Portunus pelagicus Linnaeus 1758: In silico Characterization and Phylogenetic Analysis
Vinodini Vadakkeveettil Anooja, Pokkuruparambil Prahaladhan Athira, Kesavan Dhanya, Surendran Neelima, Meethale Veedu Anju, Krishnakumar Archana, S. Muhammed Musthafa, C.K. Radhakrishnan, Rosamma Philip
In the scenario of rising multidrug resistance and allied diseases, antimicrobial peptides can be a considerable alternative for conventional antibiotics due to their broad spectrum activity and ability to bypass common resistance mechanisms. Histone derived antimicrobial peptides are found to have antibacterial, antifungal as well as anticancer properties. Here we have investigated a histone derived peptide sequence from blue swimmer crab, Portunus pelagicus for its general and immunological properties. The Pp-H2A histone derived peptide is an 8.5 kDa peptide with helical conformation on a coiled backbone. Analysis of its physicochemical characteristics such as hydrophobicity, stability and cationicity revealed its suitability as a potential drug candidate possessing antimicrobial function. According to various prediction servers, antibacterial, antifungal, anti-biofilm and anticancer properties could be attributed to the molecule. The study shall serve to strengthen the theoretical framework before proceeding for a time consuming and costly antimicrobial analysis of the molecule.
