Infliximab en el tratamiento de la enfermedad de Crohn: Estudio preliminar
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José Gellona V [1] ; Antón Zarraonandia A [1] ; Alvaro Zúñiga D [2] ; Renato Palma C [3] ; Jaime Contreras P [4] ; Jaime Silva Ch [5] ; Róbinson González D [2] ; Carlos Quintana V [2]
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[1] Universidad de Los Andes
Universidad de Los Andes
Colombia
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[2] Pontificia Universidad Católica de Chile
Pontificia Universidad Católica de Chile
Santiago, Chile
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[3] Clínica Las Condes
Clínica Las Condes
Santiago, Chile
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[4] Universidad de Chile Hospital Clínico San Borja Arriarán Departamento de Cirugía
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[5] CODELCO Hospital del Cobre
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- Localización: Revista Médica de Chile, ISSN-e 0034-9887, Vol. 134, Nº. 3, 2006, págs. 320-325
- Idioma: español
- Títulos paralelos:
- Infliximab in the treatment of patients with Crohn's disease: Preliminary report
- Enlaces
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Resumen
Background: Tumor necrosis factor alpha, interleukin 6 and 1 have a pathogenic role in Crohn's disease. Infliximab, a monoclonal antibody against tumor necrosis factor, is useful in the treatment of Crohn's disease, specially when the disease is active and associated to fistula formation. Aim: To assess the effectiveness of Infliximab in patients with Crohn's disease. Material and methods: Twelve patients with Crohn's disease (aged 16 to 63 years, 10 women) refractory to treatment with steroid, 5-aminosalicylic acid, antimicrobials and immunomodulatory drugs, were studied. A single intravenous 5 mg/kg dose Infliximab was administered. The Crohn's disease activity index (CDAI) was measured before and one week after the administration of the drug. Results: CDAI before and after Infliximab administration was 357±62 and 138±122 score points, respectively (p <0.005). According to this score, five patients had a severe and seven a moderate disease flare. The disease remitted in 7 (58%) and a clinical response was observed in 75%. Conclusions: A single dose of Infliximab was effective to induce remission of the disease in 75% of this selected group of patients with Crohn's disease
