Efecto de la administración oral de zinc sobre sensibilidad a la insulina y niveles séricos de leptina y andrógenos en hombres con obesidad

Anel Gómez-García ^[1] ; Eduardo Hernández-Salazar ^[2] ; Manuel González-Ortiz ^[2] ; Esperanza Martínez-Abundis ^[2]
1. [1] Universidad de Guadalajara
  
  Universidad de Guadalajara
  
  México
2. [2] Hospital de Especialidades
  
  Hospital de Especialidades
  
  México
Localización: Revista Médica de Chile, ISSN-e 0034-9887, Vol. 134, Nº. 3, 2006, págs. 279-284
Idioma: español
Títulos paralelos:
- Effect of oral zinc administration on insulin sensitivity, leptin and androgens in obese males
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Resumen
- Background: Zinc is important for insulin synthesis, storage and secretion. When zinc concentration decrease, there is a concomitant reduction in insulin secretion and peripheral insulin sensitivity Aim: To assess the effects of zinc sulfate on insulin sensitivity, leptin and androgens in obese individuals. Material and methods: A randomized, double-blind, placebo-controlled clinical trial was performed in 14 obese volunteers between 21 and 30 years old, with body mass index (BMI) ³ 27 kg/m2. During one month, seven subjects received 100 mg/day of zinc sulfate orally (ZnG) and the other seven received placebo, as control group (CG). At baseline and after the intervention, insulin sensitivity was measured using a euglycemic-hyperinsulinemic clamp technique. Blood glucose, serum lipids, zinc, androgens and leptin were also measured in a fasting blood sample. Results: After the intervention, a rise in zinc concentrations from 11.8 to 16.9 umol/L; p=0.001 and in leptin levels from 15.2 to 27.7 ng/mL; p=0.029, was observed in the ZnG. No changes were observed in the CG. There were no significant changes in insulin sensitivity and androgens after the intervention with zinc sulfate. Conclusions: Zinc increased the leptin concentrations in obese individuals, but did not modify insulin sensitivity and androgens