Cirrosis biliar primaria: experiencia de trece años en dos centros de referencia
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José Miguel Valera M [1] ; Gladys Smok S [1] ; Jaime Poniachik T [1] ; Danny Oksenberg R [1] ; Guillermo Silva P [2] ; Mario Ferrario B [2] ; Erwin Buckel G [2] ; Javier Brahm B [1]
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[1] Universidad de Chile
Universidad de Chile
Santiago, Chile
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[2] Clínica Las Condes
Clínica Las Condes
Santiago, Chile
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- Localización: Revista Médica de Chile, ISSN-e 0034-9887, Vol. 134, Nº. 4, 2006, págs. 469-474
- Idioma: español
- Títulos paralelos:
- Primary biliary cirrhosis: a thirteen years experience
- Enlaces
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Resumen
Background: Primary biliary cirrhosis (PBC) is a chronic cholestatic disease, which can progress to hepatic failure. Aim: To study the clinical presentation, pathological features, treatment and outcome of a group of patients with PBC. Material and methods: Retrospective review of medical records of 115 patients (110 females, age range 30-76 years) with PBC. Clinical presentation, pathological stage, treatment, outcome and eventual use of liver transplantation, were recorded. Result: Seventy eight percent of patients were symptomatic at presentation (itching in 69% and malaise in 62%). Antimitochondrial antibodies were positive in 56%. No clinical or laboratory differences were observed between symptomatic patients or those with positive antimitochondrial antibodies and the rest of the study group. Sjögren syndrome was present in 38%, hypothyroidism in 13%, scleroderma in 7% and rheumatoid arthritis in 5%. Initially, 61% had fibrosis and/or cirrhosis, and ursodeoxycholic acid was indicated in 94% of the patients. Fifteen patients underwent liver transplantation due to upper digestive bleeding or itching. Survival has been 67% at 36 months after transplantation. In one transplanted liver, PBC recurred. Conclusions: An early diagnosis and treatment of a progressive disease such as PBC will reduce the incidence of complications and the use of costly treatments
