Hipokalemia, hipovolemia y repercusión electrocardiográfica secundarias a ingesta prolongada de furosemida: Caso clínico
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César Aravena [1] ; Ignacio Salas [1] ; Rodrigo Tagle [1] ; Aquiles Jara [1] ; Rodrigo Miranda [1] ; Paul McNab [1] ; José A Rodríguez [1] ; Gloria Valdés [1] ; Andrés Valdivieso [1]
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[1] Pontificia Universidad Católica de Chile
Pontificia Universidad Católica de Chile
Santiago, Chile
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- Localización: Revista Médica de Chile, ISSN-e 0034-9887, Vol. 135, Nº. 11, 2007, págs. 1456-1462
- Idioma: español
- Títulos paralelos:
- Hypokalemia, hypovolemia and electrocardiographic changes due to furosemide abuse: Report of one case
- Enlaces
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Resumen
Hypokalemia (serum K+ < 3.5 mEq/1) is a potentially serious adverse effect of diuretic ingestión. We report a 27 year-old woman admitted with muscle weakness, a serum potassium of 2.0 mEq/1, metabolic alkalosis and EKG abnormalities simulating cardiac ischemia, that reverted with potassium chloride administration. She admitted high dose furosemide self-medication for edema. Glomerular filtration rate, tubular sodium reabsortion, potassium secretion, the renin-aldosterone system, total body water distribution and capillary permeability, were studied sequentially until 90 days after her admission. There was hyperactivity of the renin-aldosterone axis, reduction in extracellular and intracellular volumes, normal capillary permeability and high sodium tubular reabsorption, probably explained by a "rebound" salt retention associated with her decreased extracellular volume
