Aminotransferasas séricas en pacientes con Dengue tipo 3

• Nereida Valero C ^[1] ; Ivette Reyes V ^[1] ; Yraima Larreal E ^[1] ; Mery Maldonado E ^[1]
  1. [1] Universidad del Zulia Instituto de Investigaciones Clínicas Dr. Américo Negrette Sección de Virología
• Localización: Revista Médica de Chile, ISSN-e 0034-9887, Vol. 135, Nº. 10, 2007, págs. 1304-1312
• Idioma: español
• Títulos paralelos:
  • Aminotransferases serum levels in patients with Dengue type 3
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• Resumen

  • Background: Dengue infections may affect the liver, causing inflammation and compromising its function. Aim: To determine serum aminotransferases in patients with Dengue. Material and methods: One hundred eighty four patients with Dengue confirmed with anti-Dengue IgG and IgM antibodies measured by ELISA, aged 1 month to 79 years, were studied. As controls, 40 patients with acute hepatitis B virus infection aged 11 to 59 years and 40 healthy individuals, aged 14 to 55 years, were also studied. Alanine and aspartate aminotransferases (ALT and AST) were determined using a colorimetric method. Results: Sixty one percent of patients with Dengue had elevated aminotransferase levels. In patients with Dengue and hepatitis B, mean ALT levels were 21.3±8.4 and 29.7±18.8 U/I, respectively. Mean AST values were 37.3±19, 19.6± 16.4 and 4.3±1.7 U/I in patients with Dengue, hepatitis B and controls, respectively. During the year 2001, there was an increase in the number of cases with hemorrhagic fever caused by Dengue and 65% had elevation of aminotransferases. Conclusions: An increase in aminotransf erase levels is common in patients with Dengue