Distribución de las concentraciones de glucosa e indulina basal, HOMA IR Y MOMA ßcell en niños y adolescentes de la ciudad de Maracaibo, Venezuela

• Luz Marina Morales ^[1] ; Xiomara Raleigh ^[1] ; Virginia Fernández ^[1] ; Emperatriz Molero-Conejo ^[1]
  1. [1] Universidad del Zulia Facultad de Medicina Instituto de Investigaciones Clínicas
• Localización: Revista Médica de Chile, ISSN-e 0034-9887, Vol. 135, Nº. 2, 2007, págs. 205-211
• Idioma: español
• Títulos paralelos:
  • Distribution of fasting glucose, insulin, homeostasis model assessment (HOMA) insulin resistance (IR) and HOMA ß cell in children and adolescents from Maracaibo, Venezuela
• Enlaces
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• Resumen

  • Background: The raising prevalence of obesity among children increases the risk of insulin resistance and its adverse metabolic consequences. Aim: To determine the distributions of fasting serum glucose, insulin, HOMA IR and HOMA ß cell in a representative sample of children and adolescents from Maracaibo-Venezuela. Subjects and Methods: Fasting insulin and glucose were measured in 418 children and adolescents (191 boys and 227 girls) of 7, 9, 11, 13, 15 years of age. HOMA IR and HOMA ß cell were calculated. Results: Insulin levels were lower in 7 and 9 year-old girls and 7 year-old boys compared with 11, 13 and 15 year-old girls and boys. Fasting glucose concentrations were similar in boys and girls. HOMA IR was lower in 7 year-old girls compared to 11, 13 and 15 years-old girls, whereas boys in every age showed similar values. HOMA ß cell was higher in 11 and 13 year-old girls. Conclusions: Our findings provide useful values to assess insulin resistance and ß-cell functioning in children and adolescents