Relación entre niveles de carbamazepina en saliva y plasma: Estudio piloto

• Sigrid Mennickent C ^[1] ; Mario Vega H ^[1] ; Carmen Gloria Godoy M ^[1] ; M. Doris León H ^[2]
  1. [1] Universidad de Concepción

     Universidad de Concepción

     Comuna de Concepción, Chile

     
  2. [2] Hospital Las Higueras Policlínico de Neurología
• Localización: Revista Médica de Chile, ISSN-e 0034-9887, Vol. 135, Nº. 3, 2007, págs. 335-340
• Idioma: español
• Títulos paralelos:
  • Saliva and plasma levels of carbamazepine have a poor correlation: a pilot study
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• Resumen

  • Abstract: Carbamazepine is one of the most commonly used anticonvulsants for the treatment of epilepsy and its plasma concentrations must be monitored periodically to obtain a useful and safe clinical effect. There is not a good relationship between the dose of the carbamazepine and their effects in humans, but the effects of this drug have been well correlated with its plasma levels. Aim: To measure the correlation between plasma and saliva levels of carbamazepine in children with epilepsy. Material and Methods: Saliva and plasma levels of carbamazepine were measured by using instrumental planar chromatography in 11 epileptic children aged 8 to 15 years treated with the drug for at least six months. Results: The mean saliva/plasma ratio was 0.18±0.05 and the mean of carbamazepine concentration in saliva, expressed as a percentage of concentrations in plasma, was 17.97±5.40. There was a poor linear correlation (r =0.37) between the concentrations of carbamazepine in both fluids. Conclusions: In this group of epileptic children the correlation between saliva and plasma carbamazepine levels was weak