Acidosis láctica severa asociada a infusión de propofol: Caso clínico

• Carlos Romero P ^[1] ; Mónica Morales R ; Luisa Donaire R ; Osvaldo Llanos V ^[1] ; Rodrigo Cornejo R ^[1] ; Ricardo Gálvez A ^[1] ; José Castro O ^[1]
  1. [1] Universidad de Chile

     Universidad de Chile

     Santiago, Chile

     
• Localización: Revista Médica de Chile, ISSN-e 0034-9887, Vol. 136, Nº. 1, 2008, págs. 88-92
• Idioma: español
• Títulos paralelos:
  • Severe lactic acidosis caused by propofol infusion: Report of one case
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• Resumen

  • Propofol infusion syndrome (PRIS) is a rare but potentially lethal complications. This disorder is triggered under unknown circumstances by a propofol infusion of more than 5 mg/kg/h for more than 48 h. PRIS is characterized by a multiorgan failure and rhabdomyolysis and is induced by a disturbance in mitochondrial long chain fatty acid oxidation. We report a 43 year-old woman who underwent brain surgery due to a vascular malformation. In the immediate postoperative period, she had an unexplained and severe lactic acidosis. During anaesthesia, she received a propofol infusion of 7 mg/kg/h that continued in the UCI at a rate of 3.5 mg/kg/h, for 8 hours more. The suspicion of PRIS motivated immediate discontinuation of propofol with rapid correction of lactic acidosis and full recovery of the patient (Rev Méd Chile 2008; 136: 88-92)