Embriopatía por isotretinoína: Un daño evitable

• Mónica Troncoso Sen ^[2] ; Carla Rojas H ^[2] ; Eduardo Bravo C ^[1]
  1. [1] Universidad de Chile

     Universidad de Chile

     Santiago, Chile

     
  2. [2] Universidad de Chile Facultad de Medicina Hospital Clínico San Borja
• Localización: Revista Médica de Chile, ISSN-e 0034-9887, Vol. 136, Nº. 6, 2008, págs. 763-766
• Idioma: español
• Títulos paralelos:
  • Isotretinoin embryophaty: Report of one case
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• Resumen

  • Retinoic acid is a widely used drug in the treatment of cystic acné. It has teratogenic effects that depend on the gestational period in which it is used. We report a seven months of female whose mother was exposed to retinoic acid in both pregestational and gestational periods. She had a retardation of psychomotor development and a brain MRI showed frontal atrophy and a malformation of the posterior fossa. We discuss the mechanisms ofthe teratogenic effeets of retinoic acid