Marcadores de aterosclerosis temprana y síndrome metabólico en niños

Salesa Barja; Mónica Acevedo; Pilar Arnáiz Gómez; Ximena Berríos; Claudia Bambs; Beatriz Guzmán A; Jacqueline Carvajal; Berta Cassis; Carlos Navarrete

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Marcadores de aterosclerosis temprana y síndrome metabólico en niños

Salesa Barja ^[1] ; Mónica Acevedo ^[1] ; Pilar Arnaiz ^[1] ; Ximena Berríos ^[1] ; Claudia Bambs ^[1] ; Beatriz Guzmán ^[1] ; Jacqueline Carvajal ^[1] ; Berta Cassis ^[1] ; Carlos Navarrete ^[1]
1. [1] Pontificia Universidad Católica de Chile
  
  Pontificia Universidad Católica de Chile
  
  Santiago, Chile
Localización: Revista Médica de Chile, ISSN-e 0034-9887, Vol. 137, Nº. 4, 2009, págs. 522-530
Idioma: español
Títulos paralelos:
- Early markers for atherosclerosis and metabolic syndrome in children
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Resumen
- Background: The high prevalence of obesity in children favors the appearance of metabolic syndrome (MS), increasing their cardiovascular risk. Aim: To evaluate components of MSin children and to comtate them with surrogate markers of atherosclerosis and subclinical inflammation. Material and methods: We studied 209 children aged 11.5 ± 2 years (50% girls, 30% prepuberal). Fifty percent had normal weight, 18% were overweight, 29% were obese and 3% were undernourished. A fasting blood sample was obtained to measure lipid levels, glucose, insulin, adiponectin and ultrasensitive C-reactive protein (usCRP). Subclinical atherosclerosis was evaluated using flow mediated dilatation of brachial artery (FMD) and carotid intima-media thicknes (IMT). For diagnosis of MS we adapted Cook's criteria. Results: Five percent of all children and 18% ofthose with overweight had MS. Children with more components had significantly higher fasting insulin and Homeostasis Model Assessment (HOMA) values. Clustering of MS components was also associated to higher values of usCRP and non significantly to lower adiponectin levels. We did not find differences in FMD. In obese children there was a tendency towards a higher IMT with clustering of MS components, although not significant. Conclusions: Children with overweight presented a higher risk of a clusteríng of MS components, which was also associated with insulin resistance and increase in ultrasensitive C reactive protein.